14 Weeks Gestation


Case 1: Specimen and image information (ex-vivo)

Below is an annotated image of a 14 weeks and 3 days (14 + 3 weeks) old fetus with Trisomy 21, born with the amniotic sac membrane intact. The specimen was imaged ex-vivo with 3D ultrasound with CrystalVue™ and RealisticVue™ rendering.

1. Surface overview

A. 3D ultrasound volume with CrystalVue™ and RealisticVue™ applied of a fetus with Trisomy 21 at 14+3 weeks gestation, born with intact amniotic sac. The light source is placed behind the fetus enabling visualisation of the amniotic sac and insertions of the umbilical cord both into the placenta and anterior abdominal wall. 

B. Schematic illustration of the fetus and the fetal membranes. Structures with an asterisk [*] are not visible in the 3D ultrasound volume, but have been added to the schematic illustration to illustrate the relation between the developing fetus and the fetal membranes. 

C. Annotated 3D ultrasound volume.

Case 2: Specimen and image information (ex-vivo)

Below are annotated images of a healthy fetus of 14+5 weeks gestation. This specimen was imaged ex-vivo using 3D ultrasound imaging with 3D ultrasound with CrystalVue™ and RealisticVue™ rendering. Thereafter, the specimen was imaged using contrast-enhanced microCT which was used as an anatomical reference standard. The ultrasound and microCT images are directly compared, allowing for validation and annotation of the structures visualised in 3D ultrasound imaging.

1. Skeleton

A.  3D ultrasound volume with CrystalVue™ and RealisticVue™ applied (healthy 14+5 weeks gestation specimen). Settings are optimised for visualisation of skeletal structures.

B. Annotated skeletal structures.

C. Overlay of a schematic illustration of the skeletal structures visualised in the 3D ultrasound volume and the original image.

2. Renal system

A.  3D ultrasound volume with CrystalVue™ and RealisticVue™ applied (healthy 14+5 weeks gestation) specimen. The volume has been sectioned through the coronal plane of the left kidney (note that the kidney is positioned slightly obliquely in the body with its pelvis facing towards the vertebral column).

B. MicroCT image of the same specimen. A corresponding imaging plane was selected to validate the visualised structures.

C. Annotated 3D ultrasound volume based on comparison with microCT imaging as shown in image B.