16 Weeks Gestation


Case 1: Specimen and image information (ex-vivo)

Below are annotated images of a healthy 16 weeks and 2 days (16 + 2 weeks) gestation fetus, imaged ex-vivo using 3D ultrasound with CrystalVue™ and RealisticVue™ rendering.

Thereafter, the specimen was imaged using contrast-enhanced microCT which was used as an anatomical reference standard. The ultrasound and microCT images are directly compared, allowing for validation and annotation of the structures visualised in 3D ultrasound imaging. 

1. Surface overview

A-C. Increasing levels of CrystalVue™ complexity and transparency are applied to the same 3D ultrasound volume imaged with CrystalVue™ and RealisticVue™, highlighting different (internal) structures. See image below for detailed annotation of skeletal structures visualised in image C. 

2. Skeleton

A. 3D ultrasound volume with CrystalVue and RealisticVue™ rendering. Settings are optimised to highlight the skeletal structures.

B. Annotated skeletal structures.

C. Overlay of a schematic illustration of the skeletal structures visualised in the 3D ultrasound volume and the original image.

3. Thorax, diaphragm and abdominal organs

A.  3D ultrasound volume with CrystalVue™ and RealisticVue™ rendering. The volume has been sectioned in the coronal plane to highlight internal structures.

B. MicroCT image of the same specimen. A matching coronal plane was selected to validate visualised structures.

C. Annotated 3D ultrasound volume based on comparison with microCT imaging as shown in image B

4. Ventricular system and brain

A. 3D ultrasound volume CrystalVue™ and RealisticVue™ rendering. The volume has been inverted and sectioned in a parasagittal plane to highlight internal brain structures.

B. MicroCT image of the same specimen. A corresponding para-sagittal imaging plane has been selected to validate visualised structures.

C. Annotated 3D ultrasound volume based on comparison with microCT imaging as shown in image B.